研究方向

招生专业

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• 生物学

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代表性论文

l Ran Liu, Shiqi Cong, Yuan Gao, Jiaqi Xu, Xiaoxia Shi*. Application of CRISPR-Cas9-Based Gene Editing Technology in Inherited Liver Diseases. International Journal of Molecular Sciences, 2026, 27(14), 6469.

l Xiaoxia Shi*, Giulia Bortolussi*, Fanny Collaud*, Pierre-Romain Lebrun, Lysbeth Bloemendaal, Nicolas Guerchet, Dirk Rudi de Waart, Pauline Sellier, Suzanne Duijst, Philippe Veron, Federico Mingozzi, Takashi Kei Kishimoto, Giuseppe Ronzitti#, Piter Bosma#, Andrés F. Muro#, Repeated dosing of AAV-mediated liver gene therapy in juvenile rat and mouse models of Crigler-Najjar syndrome type I. Molecular Therapy Methods & Clinical Development, 2024.

l Xiaoxia Shi, Yixin Du, Shujing Li, Huijian Wu*, The Role of SUMO E3 Ligases in Signaling Pathway of Cancer Cells, International Journal of Molecular Sciences, 2022, 23(7).

l Giulia Bortolussi^#, Xiaoxia Shi^#, Lysbeth Bloemendaal, Bhaswati Banerjee, Dirk Waart, Gabriele Baj, Weiyu Chen, Ronald Oude Elferink, Ulrich Beuers, Coen Paulusma, Roland Stocker, Andrés Muro, Piter Bosma*, Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1-/- Mice: Impact on Redox Status and Metabolism, Antioxidants, 2021, 10.

l Xiaoxia Shi, Sem Aronson, Lysbeth Bloemendaal, Suzanne Duijst, Robert Bakker, Dirk Waart, Giulia Bortolussi, Fanny Collaud, Ronald Oude Elferink, Andrés Muro, Federico Mingozzi, Giuseppe Ronzitti, Piter Bosma*, Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients, Molecular Therapy-Methods & Clinical Development, 2021, 20: 287-297.

l Xiaoxia Shi*, Giulia Bortolussi, Lysbeth Ten Bloemendaal, Suzanne Duijst, Andrés F Muro, Piter J Bosma, Low efficacy of recombinant SV40 in Ugt1a1-/- mice with severe inherited hyperbilirubinemia., PLoS One, 2021, 16.

l Xiaoxia Shi*, Sem Aronson, AS Khan, Piter J Bosma. A novel UGT1A1 gene mutation causing severe unconjugated hyperbilirubinemia: a case report. BMC Pediatrics. 2019 May, 173.

l Xiaoxia Shi, Matthew Ryan Ykema, Jaco Hazenoot, Lysbeth Bloemendaal, Irene Mancini, Machteld Odijk, Peter Haan, Piter Bosma*, Cre Recombinase Mediates the Removal of Bacterial Backbone to Efficiently Generate rSV40., Molecular Therapy-Methods & Clinical Development, 2018, 9: 225-233.

l Yanan Li#, Shujing Li#, Xiaoxia Shi, Zhiqiang Xin, Yuxi Yang, Binggong Zhao, Yulin Li, linlin Lv, Ping Ren, and Huijian Wu*. KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner. Cell Death and Disease. 2023 May 8,14(5):313.

l Bowen Li#, Shujing Li#, Xiaoxia Shi, Yini Zhang, Zhiqiang Xin, Yuxi Yang, Binggong Zhao, Ping Ren*, Huijian Wu*. MZF1 (Myeloid Zinc Finger 1) activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF (P300/CBP associated factor). Genes & Diseases. 2022, ISSN 2352-3042.

l Sem Aronson, Robert Bakker, Xiaoxia Shi, Suzan Duijst, Lysbeth Bloemendaal, DR Waart, J Verheij, G Ronzitti, Ronald Oude Elferink, Ulrich Beuers, Coen Paulusma, Piter Bosma*. Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice. Journal of Hepatology. 2019 Jul,71(1):153-162.

开设课程

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  免疫学（本科生）'

  
  

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  生物化学与分子生物学实验（本科生）

  
  

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  1. 国家自然科学基金青年项目，2024-2026，主持

  
  

  2. 中国博士后国际交流计划引进项目，2021-2023，主持 

  
  

  3. 中国博士后科学基金第70批面上项目，2021-2023，主持

  
  

  4. 辽宁师范大学博士科研启动项目（自然科学类一档），2024-2026，主持

  
  

  5. 欧盟Horizon 2020计划，2018-2023，参与

  
  

  6. 荷兰科学研究与发展组织（ZonMw）基金项目，2017-2019，参与

  
  

  7. 荷兰Metakids基金项目，2016-2017，参与

  
  

  8. 国家自然科学基金面上项目，2012-2014，参与科研课题   

  
  

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荣誉奖励