履历

• ​2014/01－至今，  辽宁师范大学，生命科学学院，教授
• 2008/09－2012/06，辽宁师范大学，生命科学学院，博士
• 2004/11－2013/12，大连大学，生命科学与技术学院，副教授
• 2001/09－2004/06，辽宁师范大学，生命科学学院，硕士
• 1998/07－2001/08，宝生物工程（大连）有限公司，制造部(修饰酶精制)
• 1994/09－1998/06，辽宁师范大学，生命科学学院，学士

研究方向

• 比较免疫起源与进化研究：七鳃鳗是研究脊椎动物免疫起源与进化的重要动物模型。从分子、细胞、器官、系统多个层次探究七鳃鳗免疫与进化机制，利用比较免疫学和比较基因组学的方法纵向开展研究，试图从起源与演化的角度揭示脊椎动物免疫系统的起源与免疫机制多样性产生的机制。
• 海洋动物遗传发育研究：七鳃鳗是现存的无颌类脊椎动物代表之一，距今已有 5 亿多年的历史，素有“活化石”之称。长期的低温生活赋予七鳃鳗独特的适应生存的分子、细胞及组织特征。从基因组学、转录组学、蛋白质组学、代谢组学探究七鳃鳗进化发育分子机制，为研究生物体的进化与发育提供了坚实的理论基础。
• 天然活性产物的分离及应用：七鳃鳗是一类半寄生生物，通过吸盘吸食鱼体血肉而生存。因此，口腔腺和血清中含有独特的抗凝、抗菌及杀伤肿瘤的活性成分。分离鉴定七鳃鳗活性蛋白，揭示作用机制为产品研发及成果转化提供夯实基础。

代表性论文

• 逄越，韩英伦，李军，迟彦著《中国七鳃鳗研究：II功能基因-高迁移率族蛋白研究》，辽宁师范大学出版社，2021年.
• 李军，逄越，韩英伦编著《中国七鳃鳗研究：III早期发育和增养殖》，辽宁师范大学出版社，2021年.
• 王永奇，王威著《药用山茶的研究》，辽宁科学技术出版社，2015年，参编。
• Gou M, Duan X, Li J, Wang Y, Li Q, Pang Y*, Dong Y*. Spatial Metabolomics Reveals the Multifaceted Nature of Lamprey Buccal Gland and Its Diverse Mechanisms for Blood-Feeding. Commun Biol. 2023 Aug 28;6(1):881.
• Luan Y, Wang Y, Zhang W, Duan X, Su P, Li Q, Pang Y*, Gou M*. Identification and characterization of tryptophan-kynurenine pathway-related genes involving lamprey (Lampetra japonica) innate immunity. Fish Shellfish Immunol. 2023 Sep;140:108967.
• Wang Y, Sun F, Wang Z, Duan X, Li Q, Pang Y*, Gou M*. Peptidomics Analysis Reveals the Buccal Gland of Jawless Vertebrate Lamprey as a Source of Multiple Bioactive Peptides. Mar Drugs. 2023 Jun 29;21(7):389. 
• Li S, Zhao Z, Li Q, Li J*, Pang Y*. Lamprey Wound Healing and Regenerative Effects: The Collaborative Efforts of Diverse Drivers. Int J Mol Sci. 2023 Feb 6;24(4):3213.
• Lu J^#, Zhao Z^#, Li Q*, Pang Y*. Review of the unique and dominant lectin pathway of complement activation in agnathans. Dev Comp Immunol. 2023 Mar;140:104593.
• Wu K, Xu J, Jia Z, Wang J, Wang Z, Feng J, Zhu X, Liu Q, Wang B, Li M, Pang Y*, Zou J*. Phylogeny and expression of ADAM10 and ADAM17 homologs in lamprey. Fish Physiol Biochem. 2023 Apr;49(2):321-334. 
• Lu J^#, Duan J^#, Han Y^#, Gou M, Li J, Li Q, Pang Y*. A novel serum spherical lectin from lamprey reveals a more efficient mechanism of immune initiation and regulation in jawless vertebrates. Cell Mol Biol Lett. 2022 Nov 22;27(1):102.
• Cai Y^#, Lv W^#, Jiang Y, Li Q*, Su P*, Pang Y*. Molecular evolution of the BRINP and ASTN genes and expression profles in response to pathogens and spinal cord injury repair in lamprey (Lethenteron reissneri). Fish Shellfish Immunol. 2022 Oct 10;131:274-282.
• Du Z^#, Zhang D^#, Li J^#, Li Q, Pang Y*. Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development. Cell Commun Signal. 2022 Aug 17;20(1):124.
• Sun R^#, Wang D^#, Song Y^#, Li Q, Su P*, Pang Y*. Granulin as an important immune molecule involved in lamprey tissue repair and regeneration by promoting cell proliferation and migration. Cell Mol Biol Lett. 2022 Jul 30;27(1):64.
• Teng H^#, Li Q^#, Gou M^#, Liu G^#, Cao X, Lu J, Han Y, Yu Y, Gao Z, Song X, Dong W*, Pang Y*. Lamprey immunity protein enables early detection and recurrence monitoring for bladder cancer through recognizing Neu5Gc-modified uromodulin glycoprotein in urine. Biochim Biophys Acta Mol Basis Dis. 2022 Jul 16;1868(12):166493.
• Cao X^#, Yu S^#, Wang W^#, Sun R, Wu Z, Gao Z, Pang Y*, Li Q*. Lamprey immunity protein enables detection for bladder cancer through recognizing N-hydroxyacetylneuraminic acid (Neu5Gc)-modified as a diagnostic marker and exploration of its production mechanism. Biochem Biophys Res Commun. 2022 Jul 23;614:153-160.
• Wang X^#, Chi Y^#, Li J, Pang Y*, Li Q*. Morphological characteristics and a single-cell analysis provide insights into function of immune and fat storage in the lamprey supraneural body. Int J Biochem Cell Biol. 2022 Jan;142:106131.
• Song X^#, Xu X^#, Lu J, Chi X, Pang Y* and Li Q*. Lamprey Immune Protein Mediates Apoptosis of Lung Cancer Cells Via the Endoplasmic Reticulum Stress Signaling Pathway. Front. Oncol. 2021,11:663600.
• Ma L^#, Gou M^#, Du Z^#, Zhu T^#, Li J, Li QW, Pang Y*. MicroRNA expression profile in Lampetra morii upon Vibrio anguillarum infection and miR-4561 characterization targeting lip. Commun Biol. 2021 Aug 20;4(1):995.
• Xu X^#, Ma A^#, Li T^#, Cui W, Wang X, Li J, Li Q and Pang Y*. Genetic and Functional Characterization of Novel Brown-Like Adipocytes Around the Lamprey Brain. Front. Cell Dev. Biol. 2021, 9:674939.
• Ma A^#, Gou M^#, Song T^#, Li J, Zhu Y, Pang Y*, Li Q*. Genomic analysis and functional characterization of immune genes from the RIG-I- and MAVS-mediated antiviral signaling pathway in lamprey. Genomics. 2021;113(4):2400-2412.
• Zhu T^#, Li Y^#, Pang Y^#, Han Y^#, Li J, Wang Z, Liu X, Li H, Hua Y, Jiang H, Teng H, Quan J, Liu Y, Geng M, Li M, Hui F, Liu J, Qiu Q, Li Q*, Ren Y*. Chromosome-level genome assembly of Lethenteron reissneri provides insights into lamprey evolution. Mol Ecol Resour. 2021;21(2):448-463.
• Liu Y^#, Xu X^#, Wang X^#, Zhu T^#, Li J, Pang Y*, Li Q*. Analysis of the lamprey genotype provides insights into caspase evolution and functional divergence. Mol Immunol. 2021;132:8-20.
• Sun Z, Qin Y, Liu D, Wang B, Jia Z, Wang J, Gao Q, Zou J*, Pang Y*. The evolution and functional characterization of CXC chemokines and receptors in lamprey. Dev Comp Immunol. 2021 Mar;116:103905.
• Han Q^#, Han Y^#, Wen H, Pang Y*, Li Q*. Molecular Evolution of Apolipoprotein Multigene Family and the Original Functional Properties of Serum Apolipoprotein (LAL2) in Lampetra japonica. Front Immunol. 2020 Aug 11;11:1751.
• Hou J, Pang Y*, Li Q*. Comprehensive Evolutionary Analysis of Lamprey TNFR-Associated Factors (TRAFs) and Receptor-Interacting Protein Kinase (RIPKs) and Insights Into the Functional Characterization of TRAF3/6 and RIPK1. Front Immunol. 2020 Apr 15;11:663.
• Zhu Y, Li J, Li Q, Pang Y*. Characterization of lamprey (Lampetra japonica) tnfr10-like gene: A potential granulocyte marker molecule and its immune functions. Mol Immunol. 2020;124:25-34.
• Gou M^#, Ma L^#, Lu J^#, Wang X, Pang Y*, Li Q*. Comparative transcriptomic analysis provides insights into immune responses of lamprey larvae under three pathogens infections. Mol Immunol. 2020 Jan;117:147-154.
• Lv W^#, Ma A^#, Chi X, Li Q, Pang Y*, Su P*. A novel complement factor I involving in the complement system immune response from Lampetra morii. Fish Shellfish Immunol. 2020 Mar;98:988-994.
• Zhu Y, Pang Y*, Li Q*. Molecular evolution of the tnfr gene family and expression profiles in response to pathogens in lamprey(Lethenteron reissneri). Fish Shellfish Immunol. 2020 Jan;96:336-349.
• Guo Y^#, Li T^#, Li Q, Pang Y*, Su P*. A novel protein upstream stimulatory factor 2 identified in lamprey, Lethenteron reissneri. Dev Genes Evol. 2020 Nov;230(5-6):347-357.
• Pang Y^#, Gou M^#, Yang K^#, Lu J^#, Han Y^#, Teng H, Li C, Wang H, Liu C, Zhang K, Yang Y*, Li Q*. Crystal structure of a cytocidal protein from lamprey and its mechanism of action in the selective killing of cancer cells. Cell Commun Signal. 2019;17(1):54.
• Guan X, Lu J, Sun F, Li Q*, Pang Y*. The Molecular Evolution and Functional Divergence of Lamprey Programmed Cell Death Genes. Front Immunol. 2019;10:1382.
• Zhang K^#, Tai Z^#, Han Q^#, Pang Y*, Li Q*. Adiponectin as inducer of inflammatory and apoptosis involving in immune defense in lamprey. Fish Shellfish Immunol. 2019;90:446-455.
• Wang D^#, Gou M^#, Hou J, Pang Y*, Li Q*. The role of serpin protein on the natural immune defense against pathogen infection in Lampetra japonica. Fish Shellfish Immunol. 2019;92:196-208.
• Teng H, Wang D, Lu J, Zhou Y, Pang Y*, Li Q*. Novel insights into the evolution of the caveolin superfamily and mechanisms of antiapoptotic effects and cell proliferation in lamprey. Dev Comp Immunol. 2019;95:118-128.
• Li C, Wang D, Guan X, Liu S, Su P, Li Q*, Pang Y*. HMGB1 from Lampetra japonica promotes inflammatory activation in supraneural body cells. Dev Comp Immunol. 2019;92:50-59.
•  Pang Y, Li C, Wang S, Ba W, Yu T, Pei G, Bi D, Liang H, Pan X, Zhu T, Gou M, Han Y, Li Q*. A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells. Cell Commun Signal. 2017;15(1):42.

开设课程

• 《微生物遗传学》本科
• 《现代生物学进展》本科
• 《动物细胞工程》本科
• ​《分子生物学》研究生
• 《现代生物学研究进展》研究生

科研课题

•  李庆伟，逄越，于涛 《七鳃鳗李蛋白、制备方法及在预防和治疗肿瘤疾病中的应用》专利号：ZL201310501366.2，授权日2015年6月17日。
• 逄越，李庆伟，杨恺，张珂嘉《可作为肿瘤诊断标记物的七鳃鳗免疫蛋白LIP突变体》 专利号：ZL201910170690.8，授权日2022年3月11日。
• 逄越，李庆伟，滕洪明 《基于LIP识别尿液中修饰UMOD的Neu5Gc检验尿路上皮癌的试剂盒》专利号：ZL202011574376.5，授权日2022年6月10日。
• 逄越，李庆伟，曹旭，韩英伦《一种肝癌生物标记物及检测肝癌的试剂盒》202111416047.2，授权日2022.6.28。
• 逄越，李庆伟，滕洪明《ＬＩＰに基づいてＵＭＯＤを修飾した尿中のＮｅｕ５Ｇｃを識別する尿路上皮癌の検査用キット、およびその製造方法》 JP2021-192080，特願2021－192080，授权日2022年5月30日。
• 逄越，李庆伟，杜泽宇，韩英伦，李军，卢佳丽《七鳃鳗LIP蛋白在制备治疗肥胖和提高抗寒能力的食品和药品中的应用》申请号:202210225097.0，申请日:2022年03月09日。
• 逄越，李庆伟，曹旭，韩英伦，卢佳丽，李军《一组基于糖基化相关基因标志物在肝癌检测中的应用》申请号:202211105156.7，申请日:2022年09月09日。
• 逄越，李庆伟，吴则攀，曹旭，韩英伦，卢佳丽，李军《一种七鳃鳗血清球型凝结素、制备方法及其在肝癌检测中的应用》申请号:202211107061.9，申请日:2022年09月09日。

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